Ampicillin for Typhoid Carriers

Ampicillin Treatment of Typhoid Carriers.

THE change in the clinical course of typhoid fever due to treatment with chloramphenicol has been one of the more dramatic triumphs of the antibiotic age. A prolonged fever has been converted into a short sharp febrile illness, so that the patient suffering from the disease, instead of being dangerously ill for several weeks, may well be sitting up in bed after three or four days on chloramphen...

Treatment of chronic typhoid carriers with ampicillin.

Ten chronic enteric typhoid carriers treated with oral ampicillin have been followed for 4 to 9 years and no relapses have occurred. Patients are probably cured if relapse does not occur within 2 years.

Typhoid Fever and Typhoid Carriers

Detection of typhoid carriers by agglutination tests.

Use of the Vi agglutination test in the detection of chronic carriers of Salmonella typhi (S. typhosa) first was suggested by Felix et al. (1935). Since that time study of the test by many workers has resulted in the accumulation of a voluminous literature which has been reviewed by Klein (1943), Felix (1951), Landy and Lamb (1953), and Spaun (1957). Bhatnagar et al. (1938) recommended the use ...

Chloramphenicol combined with ampicillin in treatment of typhoid.

Fifty out of 100 patients with typhoid fever, matched for age, stage of illness, and degree of fever, were treated with chloramphenicol and the other 50 were treated with chloramphenicol combined with ampicillin. The febrile period was shortened by up to 29% in patients treated with the combined drugs compared with those given only chloramphenicol. Moreover, no patient on combined therapy had a...