منابع مشابه
Comparison of the toxicity of amphotericin B in 5% dextrose with that of amphotericin B in fat emulsion in a randomized trial with cancer patients.
A multicentric randomized trial was undertaken to compare the toxicity of amphotericin B in 5% dextrose with that of amphotericin B in a fat emulsion (Intralipid) in cancer patients. Group 1 (n = 33) received amphotericin B diluted in 5% dextrose with premedication consisting of promethazine plus an antipyretic. Group 2 (n = 28) received amphotericin B diluted in 20% Intralipid without premedic...
متن کاملEfficacy of amphotericin B in a fat emulsion for the treatment of cryptococcal meningitis in AIDS patients.
Several formulae have been developed in an attempt to reduce the toxicity of amphotericin B (AmB), but their high costs preclude widespread use. The aim of this study was to evaluate the efficacy of amphotericin B in a fat emulsion, i.e. Intralipid (AmB-IL), in 37 AIDS patients with cryptococcal meningitis (CM). We retrospectively reviewed data collected in a non-comparative open study between ...
متن کاملAmphotericin B Emulsion in Rhino - orbital Mucormycosis : Is It Most Effective ?
Mucormycosis is a fatal infection of the immunocompromised individuals. It is unusual to affect healthy individuals. The main aim of this case report is to highlight the role of amphotericin B emulsion in this disease. The case was managed in our setup with surgical debridement and followed by amphotericin B emulsion for 4 weeks. We did not notice hypokalemia and renal function test abnormality...
متن کاملAmphotericin B in children with malignant disease: a comparison of the toxicities and pharmacokinetics of amphotericin B administered in dextrose versus lipid emulsion.
In a prospective, randomized clinical trial, the toxicity of 1 mg of amphotericin B (AmB) per kg of body weight per day infused in 5% dextrose was compared with that of AmB infused in lipid emulsion in children with malignant disease. In an analysis of 82 children who received a full course of 6 days or more of AmB (117 courses), it was shown that there were significant increases in plasma urea...
متن کاملDoes lipid emulsion reduce amphotericin B nephrotoxicity? A systematic review and meta-analysis.
This meta-analysis of 13 studies revealed that amphotericin B delivered as a locally prepared lipid emulsion or in liposomes reduced nephrotoxicity to a similar degree, by 18.4% (relative risk [RR], 0.40 [99% confidence interval, .25-.64]; n = 459) and 18.1% (RR, 0.48 [99% CI, .36-.64]); n = 1233), respectively.
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ژورنال
عنوان ژورنال: American Journal of Health-System Pharmacy
سال: 1996
ISSN: 1079-2082,1535-2900
DOI: 10.1093/ajhp/53.22.2701