AMINOMETHYLATION OF DIHYDROXYACETOPHENONES
نویسندگان
چکیده
Aminomethylation of trifunctional 2.5-dihydroxyacetophenone (2.5-DHA) and 2.4-dihydro¬xy¬aceto-phenone (2.4-DHA) by free primary secondary amines in the presence formaldehyde has been conducted for first time. It established that 2.5-DHA is aminomethylated with heterocyclic - piperidine morpholine aqueous solution alcohol medium at 500C. The reaction proceeds simultaneously via all three functions forming stable C,O-substitution products − β-amino-2-aminomethoxy-4-aminomethyl-5-hydroxypropiophenones. aminomethylation 2.4-DHA phenolic function only under action methylene bis-amines absolute 200C formation 2.4-dihydroxy-3-aminomethylacetophenones. aromatic n-to¬luidine n-anisidine form paraform catalytic amounts KOH are 3.4-dihydro-2H-1.3-benzoxazines. does not react formaldehyde. composition structure compounds synthesized have according to data ele¬mental spectral methods analysis
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ژورنال
عنوان ژورنال: Azerbaj?an himiâ žurnaly
سال: 2022
ISSN: ['2522-1841', '0005-2531']
DOI: https://doi.org/10.32737/0005-2531-2022-3-81-86