Aminoglycoside ototoxicity susceptibility in cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Otoacoustic emissions for monitoring aminoglycoside-induced ototoxicity in children with cystic fibrosis.
OBJECTIVE To investigate whether transient-evoked and distortion-product (DP) otoacoustic emissions (OAEs) are more sensitive than pure-tone audiometry (PTA) in revealing gentamicin-induced ototoxicity in children with cystic fibrosis (CF). DESIGN Prospective case-control study. SETTING Tertiary referral audiologic center in conjunction with an academic pediatric CF unit. PARTICIPANTS The...
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Abstract Background and Objective: Cystic fibrosis (CF) is an autosomal recessive genetic disease and Pseudomonas aeruginosa is one of the most common bacteria colonized in CF patients. Growing resistance of this bacterium to antibiotics now a day is a challenge of controlling infection in CF patient. In this study colonization of CF patients with Pseudomonas aeruginosa and antibiotic suscep...
متن کاملMinimisation of aminoglycoside toxicity in patients with cystic fibrosis.
BACKGROUND There is evidence that administration of higher doses of aminoglycosides given less frequently improves the bactericidal effect and reduces the potential to cause side effects. To investigate this, a prospectively randomised open label therapeutic trial was undertaken in stratified groups of patients with cystic fibrosis to examine the efficacy and toxic potential of an aminoglycosid...
متن کاملRenal impairment following aminoglycoside therapy in cystic fibrosis.
Cystic fibrosis (CF) is a chronic respiratory, life limiting illness in the Caucasian population. Chronic infection with Pseudomonas aeruginosa occurs in more than 80% of adults and this contributes to deterioration in lung function over time. A reported long term complication includes renal impairment from presumed cumulative aminoglycoside antibiotics. Aminoglycosides are highly effective aga...
متن کاملPrevention and modulation of aminoglycoside ototoxicity (Review).
More than 60 years after their isolation and characterization, aminoglycoside (AG) antibiotics remain powerful agents in the treatment of severe gram-negative, enterococcal or mycobacterial infections. However, the clinical use of AGs is hampered by nephrotoxicity and ototoxicity, which often develop as a consequence of prolonged courses of therapy, or of administration of increased doses of th...
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ژورنال
عنوان ژورنال: Thorax
سال: 2009
ISSN: 0040-6376
DOI: 10.1136/thx.2008.103010