منابع مشابه
Aminoglycoside Antibiotics
Aminoglycosides are hydrophilic, polycationic, aminecontaining carbohydrates that are usually composed of three to five rings. Most aminoglycosides are either natural products or derivatives of soil actinomycetes. They are often secreted by these actinomycetes as mixtures of closely related compounds. The polycationic aminoglycoside chemical structure results in a binding both to the anionic ou...
متن کاملAminoglycoside antibiotics inhibit protein biosynthesis
RNA molecules have key roles in many essential biological processes, including protein synthesis, transcriptional regulation, mRNA splicing and retroviral replication. The structural diversity of RNA, together with the lack of known RNA repair mechanisms, make RNA a challenging and important target for therapeutic intervention [1]. Our understanding of the modes by which RNA is recognized by li...
متن کاملDNA-Aptamers Binding Aminoglycoside Antibiotics
Aptamers are short, single stranded DNA or RNA oligonucleotides that are able to bind specifically and with high affinity to their non-nucleic acid target molecules. This binding reaction enables their application as biorecognition elements in biosensors and assays. As antibiotic residues pose a problem contributing to the emergence of antibiotic-resistant pathogens and thereby reducing the eff...
متن کاملDNA triple helix stabilization by aminoglycoside antibiotics.
The stabilization of the poly(dA) x 2poly(dT) triple helix by neomycin is reported. Preliminary results indicate that neomycin stabilizes DNA triple helices and the double helical structures composed of poly(dA) x poly(dT) are virtually unaffected. This is the first report of the interaction of aminoglycoside antibiotics with DNA triple helices.
متن کاملModulation of RNA function by aminoglycoside antibiotics.
One of the most important families of antibiotics are the aminoglycosides, including drugs such as neomycin B, paromomycin, gentamicin and streptomycin. With the discovery of the catalytic potential of RNA, these antibiotics became very popular due to their RNA-binding capacity. They serve for the analysis of RNA function as well as for the study of RNA as a potential therapeutic target. Improv...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1974
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.27.471