Ameliorative Processes of Beta-Carotene in Streptozotocin-Induced Diabetic Vascular Dementia in Rats

Beta-carotene (BC) is a precursor of vitamin A and an excellent antioxidant. It protects the vascular system. Vascular dementia (VaD) one aging disorders causing memory dysfunction. The available medicines for management VaD are limited. present study aimed to evaluate ameliorative effect BC in streptozotocin (STZ)-induced diabetic rats. Diabetic was induced through administration nicotinamide (NA, 50 mg/kg; i.p.) STZ (50 i.p.). test compound 100 p.o.) reference donepezil (1 were administered 15 consecutive days. Cognitive changes assessed by transfer latency (TL) using elevated plus maze (EPM) test. acetylcholinesterase (AChE) activity estimated septohippocampal system rat brains. caused significant cognitive functions (increased TL) as compared normal group. ameliorated anxiety-related behavior neurotransmitter (elevated AChE) provoked VaD. Therefore, could be potential therapeutic candidate