Ameliorative Effect of Sesamin in Cisplatin-Induced Nephrotoxicity in Rats by Suppressing Inflammation, Oxidative/Nitrosative Stress, and Cellular Damage
نویسندگان
چکیده
منابع مشابه
Effect of Simvastatin on Cisplatin-induced Nephrotoxicity in Male Rats
Statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. This study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. Simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). All animals we...
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15 صفحه اولAmeliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death
Oxidative stress and inflammation are part and parcel of cisplatin-induced nephrotoxicity. The purpose of this work is to study the role of soy isoflavone constituent, daidzein, in cisplatin-induced renal damage. Cisplatin-induced nephrotoxicity was evident by the histological damage in proximal tubular cells and by the increase in serum neutrophil gelatinase-associated lipocalin (NGAL), blood ...
متن کاملProtective Effect of P-Coumaric Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity in Rats
Background and purpose: Cisplatin is used in chemotherapy for cancer patients. But, it has adverse effects on some organs, including the kidney and liver. P-coumaric acid is a polyphenolic substance with multiple biological properties. The present study aimed to investigate the effect of p-coumaric acid on renal and hepatic side effects of cisplatin. Materials and methods: This experimental st...
متن کاملEffect of Glutathione on Cisplatin-Induced Nephrotoxicity in Male and Female Rats
SUMMARY Cisplatin is a widely used anticancer agents that is effective against ovarian and other tumors. This drug is recognized as nephrotoxic in human and experimental animals. The effect of cisplatin-induced kidney injury was predominantly investigated in male animals. This study was designed to assess effects of cisplatin on male and female rat kidneys. We also investigated the effect of g...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2020
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.934142