Amelioration of Ischemic Acute Renal Injury by Neutrophil Gelatinase-Associated Lipocalin
نویسندگان
چکیده
منابع مشابه
Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin.
Acute renal failure secondary to ischemic injury remains a common problem, with limited and unsatisfactory therapeutic options. Neutrophil gelatinase-associated lipocalin (NGAL) was recently shown to be one of the maximally induced genes early in the postischemic kidney. In this study, the role of NGAL in ischemic renal injury was explored. Intravenous administration of purified recombinant NGA...
متن کاملNeutrophil Gelatinase-Associated Lipocalin and Contrast-Induced Acute Kidney Injury.
BACKGROUND Neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of acute kidney injury (AKI). METHODS AND RESULTS Urine NGAL and serum NGAL (sNGAL) were assessed at 2, 6, 24, and 48 hours after contrast media (CM) exposure in 458 high-risk patients (development set). Optimal thresholds in predicting contrast-induced AKI (serum creatinine [sCr] increase ≥0.3 mg/dL at 48 hours a...
متن کاملIdentification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury.
Acute renal failure (ARF) secondary to ischemic injury remains a common and potentially devastating problem. A transcriptome-wide interrogation strategy was used to identify renal genes that are induced very early after renal ischemia, whose protein products might serve as novel biomarkers for ARF. Seven genes that are upregulated >10-fold were identified, one of which (Cyr61) has recently been...
متن کاملEffects of Hemodilution and Transfusion on Acute Renal Injury and Neutrophil Gelatinase-Associated Lipocalin-Author's Reply.
Address for Correspondence: Dr. Jülide Sayın Kart, Acıbadem Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, İstanbul, Türkiye Phone: +90 216 544 40 77 E-mail: [email protected] ©Copyright 2015 by Turkish Anaesthesiology and Intensive Care Society Available online at www.jtaics.org Received : 17.11.2014 Accepted : 20.12.2014 Available Online Date : 16.02.2015 Jülid...
متن کاملRenal neutrophil gelatinase associated lipocalin expression in lipopolysaccharide-induced acute kidney injury in the rat
BACKGROUND Neutrophil gelatinase associated lipocalin (NGAL) is a highly predictive biomarker of acute kidney injury. To understand the role of NGAL in renal injury during sepsis, we investigated the temporal changes and biological sources of NGAL in a rat model of acute kidney injury, and explored the relationship between renal inflammation, humoral NGAL and NGAL expression during endotoxemia....
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2004
ISSN: 1046-6673,1533-3450
DOI: 10.1097/01.asn.0000145013.44578.45