AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity

Dual effect of AMD3100, a CXCR4 antagonist, on bleomycin-induced lung inflammation.

The chemokine receptor CXCR4, which binds the chemokine stromal cell-derived factor 1, has been reported to be involved in the chemotaxis of inflammatory cells. In addition, AMD3100, an antagonist of CXCR4, has been reported to be an attractive drug candidate for therapeutic intervention in several disorders in which CXCR4 is critically involved. However, little is known about the therapeutic v...

Inflammation in Mice A20 Attenuates Allergic Airway

Pravastatin attenuates allergic airway inflammation Page 1 Pravastatin attenuates allergic airway inflammation by suppressing antigen-sensitization, IL-17 production, and antigen-presentation in the lung

Background: Statins are widely used to treat hyperlipidemia. Their immunosuppressive effect has recently been confirmed in various immune-mediated disease models. However, relatively few studies have been conducted on allergic inflammation, so the precise mechanisms of their actions against allergies have not been fully clarified. On the other hand, the role of interleukin (IL)-17 in immune res...

Sappanone A Attenuates Allergic Airway Inflammation in Ovalbumin-Induced Asthma.

BACKGROUND Sappanone A (SA) is isolated from the heartwood of Caesalpinia sappan and exerts a wide range of pharmacological activities. In the present study, we investigated the protective effects of SA on allergic asthma in a murine model of ovalbumin (OVA)-induced asthma. METHODS BALB/c mice were sensitized and challenged. Then, the mice were intraperitoneally injected with SA (12.5, 25 and...

CXCR4 Antagonist AMD3100 Accelerates Impaired Wound Healing in Diabetic Mice

The antagonism of CXC-chemokine receptor 4 (CXCR4) with AMD3100 improves cardiac performance after myocardial infarction by augmenting the recruitment of endothelial progenitor cells (EPCs) from the bone marrow to the regenerating vasculature. We investigated whether AMD3100 may accelerate diabetes-impaired wound healing through a similar mechanism. Skin wounds were made on the backs of leptin ...