Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice
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چکیده
منابع مشابه
Ambroxol effects in glucocerebrosidase and α‐synuclein transgenic mice
OBJECTIVE Gaucher disease is caused by mutations in the glucocerebrosidase 1 gene that result in deficiency of the lysosomal enzyme glucocerebrosidase. Both homozygous and heterozygous glucocerebrosidase 1 mutations confer an increased risk for developing Parkinson disease. Current estimates indicate that 10 to 25% of Parkinson patients carry glucocerebrosidase 1 mutations. Ambroxol is a small ...
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Mutations in the GBA1 gene are associated with increased risk of Parkinson's disease, and the protein produced by the gene, glucocerebrosidase, interacts with α-synuclein, the protein at the center of the disease etiology. One possibility is that the mutations disrupt a beneficial interaction between the proteins, and a beneficial interaction would imply that the proteins have coevolved. To exp...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2016
ISSN: 0364-5134
DOI: 10.1002/ana.24790