Alzheimer hotspot on 10

Heatflow on Hotspot Planets : 10 and Venus

On planets where most of the heat is transported to the surface by igneous activity (extrusive volcanism or near-surface intrusions), the surface heat flow at localities well away from regions of current igneous activity need not be even approximately the conductive heatflow through the entire lithosphere but may instead be dominated by the residual heat leaking out from the last igneous event ...

Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease.

With the exception of ApoE (APOE), no universally accepted genetic association has been identified with late-onset Alzheimer disease (AD). A broad region of chromosome 10 has engendered continued interest generated from both preliminary genetic linkage and candidate gene studies. To better examine this region, we combined unbiased genetic linkage with candidate gene association studies. We geno...

Lock optimizations on the HotSpot VM

This report gives an overview of different optimisations made by the Java HotSpot VM to decrease the overhead of synchronisation. It lists the major strategies, explains why they work and provides and cites some rudimentary benchmarking to prove that they work.

Update on Alzheimer drugs (donepezil).

BACKGROUND Several clinical trials have been conducted over a period of many years reporting the benefits of donepezil for Alzheimer disease (AD) patients. REVIEW SUMMARY Randomized, double-blind, placebo-controlled stud-ies of 3-6 months' duration have demonstrated significant benefits for 5mg/D and 10 mg/D of donepezil compared with placebo. The results include benefits for cognition, activ...

Update on Alzheimer ’ s Disease