منابع مشابه
Parallel Alternating-Direction Access Machine
This paper presents a theoretical study of a model of parallel computations called Parallel Alternating-Direction Access Machine (padam). padam is an abstraction of the multiprocessor computers adena /adenart and a prototype architecture usc/omp. The main feature of padam is the organization of access to the global memory: (1) the memory modules are arranged as a 2-dimensional array, (2) each p...
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Crystal structures of LeuT, a bacterial homologue of mammalian neurotransmitter transporters, show a molecule of bound substrate that is essentially exposed to the extracellular space but occluded from the cytoplasm. Thus, there must exist an alternate conformation for LeuT in which the substrate is accessible to the cytoplasm and a corresponding mechanism that switches accessibility from one s...
متن کاملParallel Alternating - Direction Access Machine ? Bogdan
This paper presents a theoretical study of a model of parallel computations called Parallel Alternating-Direction Access Machine (padam). padam is an abstraction of the multiprocessor computers adena /adenart and a prototype architecture usc/omp. The main feature of padam is the organization of access to the global memory: (1) the memory modules are arranged as a 2-dimensional array, (2) each p...
متن کاملLactose permease and the alternating access mechanism.
Crystal structures of the lactose permease of Escherichia coli (LacY) reveal 12, mostly irregular transmembrane α-helices surrounding a large cavity open to the cytoplasm and a tightly sealed periplasmic side (inward-facing conformation) with the sugar-binding site at the apex of the cavity and inaccessible from the periplasm. However, LacY is highly dynamic, and binding of a galactopyranoside ...
متن کاملMechanism of Substrate Translocation in an Alternating Access Transporter
Transporters shuttle molecules across cell membranes by alternating among distinct conformational states. Fundamental questions remain about how transporters transition between states and how such structural rearrangements regulate substrate translocation. Here, we capture the translocation process by crystallography and unguided molecular dynamics simulations, providing an atomic-level descrip...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.2998