منابع مشابه
Human tumour-associated and tumour-specific antigens: some concepts in relation to clinical oncology.
The concept of tumour-specific antigens is constantly undergoing reappraisal with the development of more sensitive methods for their detection. This has resulted in the finding that the many 'new' antigens produced by human tumours or materials immunologically closely related to them are also present in non-neoplastic tissues, albeit in small amounts. However, other antigens still appear to ex...
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Considerable progress has been made in the last few decades in the identification of defined tumour-associated antigens recognized by monoclonal antibodies (mAbs). The generation of mAbs against tumour antigens has principally been through standard hybridoma techniques following immunization of mice, while in the last decade recombinant phage display technology has also been employed. Much of t...
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The development of efficient, cell surface targeted retroviral vectors is critical for successful gene therapy as gene delivery to non-target cells may be harmful and would deplete the pool of viral particles. To date, the only surface-targeting strategies that have allowed efficient infection by retroviral vectors in vivo are those that have limited the tropism of amphotropic murine leukaemia ...
متن کاملClinical value of tumour-associated antigens.
Since the first clear demonstration of the existence of 'specific' antigens in experimental tumours (Gross, 1943; Foley, 1953), the extensive use of syngeneic animals has resulted in the identification of tumour-associated or characteristic macromolecules ('antigens') in association with spontaneously occurring or experimentally induced tumours (Old and Boyse, 1964; Baldwin, 1970; Stonehill and...
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Tumour associated antigens recognised by cellular or humoral effectors of the immune system are potential targets for antigen specific cancer immunotherapy. Different categories of cancer antigens have been identified that induce cytotoxic T lymphocyte (CTL) responses in vitro and in vivo, namely: (1) "cancer testis" (CT) antigens, expressed in different tumours and normal testis, (2) melanocyt...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2019
ISSN: 1474-175X,1474-1768
DOI: 10.1038/s41568-019-0162-4