Alternative Sampling Devices to Collect Dried Blood Microsamples

Dried blood spots (DBS) have been used in newborn screening programs for several years. More recently, there has growing interest using DBS as a home sampling tool the quantitative determination of analytes. However, this presents challenges, mainly because well-known hematocrit effect and other DBS-specific parameters, including spotted volume punch site, which could add to method uncertainty. Therefore, new microsampling devices that quantitatively collect capillary dried are continuously being developed. In review, we provided an overview commercially available or under development allow (volumetric) collection (-based) microsamples meant be remote sampling. Considering field therapeutic drug monitoring (TDM), examined different aspects important device implemented clinical practice, ease patient use, technical performance, integration workflow laboratory. Costs related briefly discussed, additionally plays role decision-making process. Although added value TDM willingness patients perform demonstrated some studies, real implementation is progressing at slower pace. extensive evaluation these newly developed devices, not only analytically but also clinically, needed demonstrate their real-life applicability, prerequisite use TDM.