Altered Structure and Function of Reproductive Organs in Transgenic Male Mice Overexpressing Human Aromatase*

Altered Structure and Function of Reproductive Organs in Transgenic Male Mice Overexpressing Human Aromatase.

Aromatization of androgens is a key step in estrogen production, and it regulates the delicate balance between estrogens and androgens in the gonads and sex steroid target tissues. In the present study, we generated transgenic mice (AROM(+)) bearing the human ubiquitin C promoter/human P450 aromatase fusion gene. AROM(+) male mice are characterized by an imbalance in sex hormone metabolism, res...

Selenium in human male reproductive organs.

The objective of the study was to obtain information on the concentration and distribution of selenium throughout the human male reproductive tract. Material was removed at autopsy from 41 men who had died suddenly and unexpectedly. Semen samples were also provided from 184 men attending an andrology clinic for fertility investigation and from 32 healthy volunteers. Significant positive correla...

Study on The Reproductive Organs and Fertility of The Male Mice following Administration of Metronidazole

Altered function in atrium of transgenic mice

UWE KIRCHHEFER,1 HIDEO A. BABA,2 YVONNE M. KOBAYASHI,3 LARRY R. JONES,3 WILHELM SCHMITZ,1 AND JOACHIM NEUMANN1 1Institut für Pharmakologie und Toxikologie, Westfälische Wilhelms-Universität, 48149 Münster; 2Institut für Pathologie, Universität Essen, 45147 Essen, Germany; and 3Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana ...

Galanin overexpressing transgenic mice.

Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT). Performance deficits on learning and memory tasks, impaired long-term potentiation, reduced hippocampal excitability, lower evoke...