Altered Mitochondrial Anatomy of Trigeminal Ganglia Neurons in Diabetes
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منابع مشابه
Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia.
The use of Cre-loxP technology for conditional mutagenesis in pain pathways had been restricted by the unavailability of mice expressing Cre recombinase selectively in functionally distinct components of the nociceptive system. Here we describe the generation of transgenic mouse lines which express Cre recombinase selectively in sensory ganglia using promoter elements of the Na(v)1.8 gene (Scn1...
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The TG represents a cranial analog of the dorsal root ganglia in the peripheral nervous system (Darian-Smith, 1973). TG neurons have a unique morphology and are classified as pseudounipolar (Krastev, 2009). Their centripetal processes, usually called trigeminal primary afferents, carry somatosensory information from mechanoreceptors, thermoreceptors and nociceptors in the face, the oral and nas...
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The cell bodies of pseudounipolar neurons of the trigeminal ganglia have been presumed to play a supportive role to neurites, which transmit various sensations like pain from the periphery to the brain stem. However, several studies have recently shown that these neuronal cell bodies could modulate the afferent stimuli by up-regulating various ion channels and also by increasing the synthesis o...
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BACKGROUND Endothelial dysfunction contributes to the development of atherosclerosis in patients with diabetes mellitus, but the mechanisms of endothelial dysfunction in this setting are incompletely understood. Recent studies have shown altered mitochondrial dynamics in diabetes mellitus with increased mitochondrial fission and production of reactive oxygen species. We investigated the contrib...
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ژورنال
عنوان ژورنال: The Anatomical Record
سال: 2016
ISSN: 1932-8486
DOI: 10.1002/ar.23475