Altered denA and anr gene expression in aminoglycoside adaptive resistance in Pseudomonas aeruginosa

Aminoglycoside resistance in Pseudomonas aeruginosa.

In vitro characterization of aminoglycoside adaptive resistance in Pseudomonas aeruginosa.

Aminoglycoside adaptive resistance was characterized in one reference strain and four clinical isolates of Pseudomonas aeruginosa. Adaptive resistance was initiated with a 2-h gentamicin or tobramycin exposure at the MIC. Each P. aeruginosa strain demonstrated an adaptive-resistance period of between 8 and 12 h when tested with both aminoglycosides. Aminoglycoside adaptive resistance was shown ...

Lability of Resistance to Aminoglycoside Antibiotics in Pseudomonas Aeruginosa

The determinants for resistance to aminoglycoside antibiotics in some strains of Pseudomonas aeruginosa were irreversively lost during storage or by treatment with ethidium bromide. This fact has indicated the presence of plasmids governing resistance to aminoglycosides in the pseudomonads as well as R factor in gram-negative enteric bacteria and plasmid in staphylococci. Many papers have descr...

Aminoglycoside resistance of Pseudomonas aeruginosa biofilms modulated by extracellular polysaccharide.

Pseudomonas aeruginosa is an opportunistic pathogen that produces sessile communities known as biofilms that are highly resistant to antibiotic treatment. Limited information is available on the exact role of various components of the matrix in biofilm-associated antibiotic resistance. Here we show that the presence of extracellular polysaccharide reduced the extent of biofilm-associated antibi...

Links between Anr and Quorum Sensing in Pseudomonas aeruginosa Biofilms.

UNLABELLED In Pseudomonas aeruginosa, the transcription factor Anr controls the cellular response to low oxygen or anoxia. Anr activity is high in oxygen-limited environments, including biofilms and populations associated with chronic infections, and Anr is necessary for persistence in a model of pulmonary infection. In this study, we characterized the Anr regulon in biofilm-grown cells at 1% o...