Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior
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منابع مشابه
Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior
Based on studies in mice and humans, cohesin loss from chromosomes during the period of protracted meiotic arrest appears to play a major role in chromosome segregation errors during female meiosis. In mice, mutations in meiosis-specific cohesin genes cause meiotic disturbances and infertility. However, the more clinically relevant situation, heterozygosity for mutations in these genes, has not...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2013
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1003241