Alterations in intrinsic neuronal excitability during normal aging
نویسندگان
چکیده
منابع مشابه
Learning and Aging Related Changes in Intrinsic Neuronal Excitability
A goal of many laboratories that study aging is to find a key cellular change(s) that can be manipulated and restored to a young-like state, and thus, reverse the age-related cognitive deficits. We have chosen to focus our efforts on the alteration of intrinsic excitability (as reflected by the postburst afterhyperpolarization, AHP) during the learning process in hippocampal pyramidal neurons. ...
متن کاملAlterations in canine myocardial excitability during ischemia.
Changes in the ventricular diastolic excitability threshold following occlusion of the left anterior descending coronary artery (LAD) were studied in open-chest anesthetized dogs by using a new automatic threshold-following pacemaker (ATFP). The ATFP measures the diastolic excitability threshold by successively decreasing the duration of regularly occurring pacing stimuli until the ventricle fa...
متن کاملPsychostimulant-induced plasticity of intrinsic neuronal excitability in ventral subiculum.
Psychostimulant drugs such as amphetamine are prescribed to increase vigilance, suppress appetite, and treat attention disorders, but they powerfully activate the dopamine system and have serious abuse potential. Repeated psychostimulant exposure induces neuronal plasticity within the mesolimbic dopamine system. Here we present evidence that repeated amphetamine exposure results in a suppressio...
متن کاملIntrinsic Neuronal Excitability: A Role in Homeostasis and Disease
The neuronal components of brain circuitry are generally considered “stable” throughout an animals’ life; with the exception of times of growth and degeneration that occur during development, aging, or pathology. To maintain this stability, neurons must achieve a balance between changing output to meet new requirements, and keeping output within a satisfactory operating range. This balancing ac...
متن کاملSleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability
BACKGROUND Emerging data suggest an important relationship between sleep and Alzheimer's disease (AD), but how poor sleep promotes the development of AD remains unclear. RESULTS Here, using a Drosophila model of AD, we provide evidence suggesting that changes in neuronal excitability underlie the effects of sleep loss on AD pathogenesis. β-amyloid (Aβ) accumulation leads to reduced and fragme...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging Cell
سال: 2007
ISSN: 1474-9718,1474-9726
DOI: 10.1111/j.1474-9726.2007.00297.x