Alteration of indicator gut microbiota in patients with chronic sinusitis

Abstract Background Many factors influence the composition of sinus microflora. The microbial balance is most disturbed by use antibacterial agents. Superinfections caused more than one pathogen may then occur. Despite treatment, including surgery and long‐term antibiotic therapy, many patients with sinusitis do not experience significant relief from their symptoms. It has been hypothesized that an imbalance in gut microbiota also be responsible for chronicity sinusitis. Our goal was therefore to identify selected indicator bacteria play a role immunity chronic In addition, compare number two groups patients: rhinosinusitis (CRS) concomitant diseases and/or symptoms other CRS. Results Significantly decreased numbers Bifidobacterium spp. Faecalibacterium prauznitzi were observed G1 group. majority this group (12 out 13) had significantly Akkermansia muciniphila bacteria, which are involved nutrition regeneration epithelium cells have anti‐inflammatory properties. G2 (patients comorbidities) F. prausnitzii, spp., A. Lactobacillus observed. A small percentage showed overgrowth yeast‐like fungi. Conclusion Although research needed, possibly analyses might enable plan personalized prebiotic probiotic could support intestine mucosal suffering