Alteration of gene expression by alcohol exposure at early neurulation
نویسندگان
چکیده
منابع مشابه
Cellular DNA methylation program during neurulation and its alteration by alcohol exposure.
BACKGROUND Epigenetic changes are believed to be among the earliest key regulators for cell fate and embryonic development. To support this premise, it is important to understand whether or not systemic epigenetic changes coordinate with the progression of development. We have demonstrated that DNA methylation is programmed when neural stem cells differentiate (Zhou et al.,2011). Here, we analy...
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BACKGROUND Fetal alcohol exposure causes growth deficits, microencephaly, and neurological abnormalities. Although the effects of alcohol on developmental delay and growth-related deficits have been hypothesized, little is understood about how alcohol alters, in particular, the cyclin pathway within the cell cycle, which is critical to proliferation and apoptotic control. In this study, we exam...
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Background: Fetal alcohol exposure causes growth deficits, microencephaly, and neurological abnormalities. Although the effects of alcohol on developmental delay and growth-related deficits have been hypothesized, little is understood about how alcohol alters, in particular, the cyclin pathway within the cell cycle, which is critical to proliferation and apoptotic control. In this study, we exa...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2011
ISSN: 1471-2164
DOI: 10.1186/1471-2164-12-124