منابع مشابه
Temporal bone histopathology of furosemide ototoxicity
OBJECTIVES To describe the human temporal bone pathology in two patients who incurred furosemide induced ototoxicity. PATIENTS 1) A 46-year-old woman in acute liver and renal failure treated with high doses of furosemide for anasarca who developed a rapidly progressive severe-to-profound asymmetric sensorineural hearing loss. 2) A 65-year-old woman with undifferentiated small cell carcinoma o...
متن کاملSildenafil and furosemide associated ototoxicity: consideration of drug-drug interactions, synergy, and broader clinical relevance.
Drug-induced ototoxicity, particularly those involving phosphodiesterase type 5 (PDE-5) inhibitors, is considered to be rare and to our knowledge such an adverse effect has not been reported in Canada. Here we present a case of a 77-year old man initiated on a sildenfil regimen for the treatment of pulmonary hypertension, who developed sudden bilateral hearing loss after taking sildenafil, in t...
متن کاملKanamycin-furosemide ototoxicity in the mouse cochlea: a 3-dimensional analysis.
OBJECTIVE Administration of an aminoglycoside antibiotic and loop diuretic causes damage to hair cells in the organ of Corti, resulting in their death and the death of their corresponding spiral ganglion neurons. While this phenomenon has been studied previously, analysis of its effects in the whole cochlea has not been reported. The authors sought to evaluate the effects of a combination dose ...
متن کاملObjective Measures of Ototoxicity
A leading cause of preventable sensorineural hearing loss is therapeutic treatment with medications that are toxic to inner ear tissues, including certain drugs used to fight cancer and life-threatening infectious diseases. Ototoxic-induced hearing loss typically begins in the high frequencies and progresses to lower frequencies as drug administration continues (Campbell & Durrant, 1993; Campbe...
متن کاملAntihypertensive properties of furosemide.
The antihypertensive properties of single doses of furosemide were evaluated in 113 patients. Doses over 120 mg consistently produced a fall in arterial pressure whereas smaller doses did not. Thus 20 of 22 patients (90%) who received more than 120 mg had a 26 + 6% average reduction in mean arterial pressure. The hypotensive action began in 30 to 45 minutes, the nadir of the decrease occurred b...
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ژورنال
عنوان ژورنال: The Journal of the Acoustical Society of America
سال: 1982
ISSN: 0001-4966
DOI: 10.1121/1.2019909