Alpha-Mangostin Suppresses LPS-Induced Inflammation in Human Dental Pulp Cells

نویسندگان

چکیده

Xanthones are secondary metabolites isolated from the peel of mangosteen showing medicinal potencies. Alpha-mangostin (α-MG) is most plentiful xanthone, which has been reported to possess anti-inflammatory, anti-oxidant, and anti-bacterial activities. We aimed investigate anti-inflammatory effects xanthones on LPS-treated hDPCs. Cell viability was determined using WST-1 assay. The mRNA protein expression profiles inflammatory mediators were evaluated quantitative real-time polymerase chain reaction (qPCR) Western blot analysis. Anti-inflammatory assessed analysis examine underlying mechanisms. A one-way variance followed by Tukey’s post hoc test used determine statistically significant differences (p < 0.05). study found no between cytotoxic in α-MG-treated groups controls. levels markers α-MG treated decreased. significantly inhibited LPS-induced phosphorylation proteins associated with MAPK NF-κB pathways. This suggests that exerts suppressing signaling pathways

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1Department of Conservative Dentistry, College of Dentistry, Kyung Hee University, Seoul 02447, Republic of Korea 2The State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Sichuan 610042, China 3Department of Restorative Dentistry, University of Otago, School of Dentistry, Dunedin 9016, New Zealand 4Department of Oral Biological Sciences, University Lyon ...

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ژورنال

عنوان ژورنال: Applied sciences

سال: 2023

ISSN: ['2076-3417']

DOI: https://doi.org/10.3390/app13020681