Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress
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منابع مشابه
Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress.
BACKGROUND S-nitrosylation of mitochondrial enzymes involved in energy transfer under nitrosative stress may result in ATP deficiency. We investigated whether α-lipoic acid, a powerful antioxidant, could alleviate nitrosative stress by regulating S-nitrosylation, which could result in retaining the mitochondrial enzyme activity. METHODS In this study, we have identified the S-nitrosylated for...
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متن کاملAlpha-lipoic acid supplementation and diabetes
Diabetes is a common metabolic disorder that is usually accompanied by increased production of reactive oxygen species or by impaired antioxidant defenses. Importantly, oxidative stress is particularly relevant to the risk of cardiovascular disease. Alpha-lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an essential cofactor for mitochondrial bioenergetic enzymes...
متن کاملAlpha-lipoic acid supplementation and diabetes.
Diabetes is a common metabolic disorder that is usually accompanied by increased production of reactive oxygen species or by impaired antioxidant defenses. Importantly, oxidative stress is particularly relevant to the risk of cardiovascular disease. Alpha-lipoic acid (LA), a naturally occurring dithiol compound, has long been known as an essential cofactor for mitochondrial bioenergetic enzymes...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2016
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2015.09.001