ALPHA-GLUCOSIDASE INHIBITOR ACTIVITIES AND PHYTOCHEMICALS SCREENING OF THE PEPEROMIA GENUS CULTIVATED IN INDONESIA

Objective: Peperomia is a genus belong to Piperaceae family, which valuable as ornamental and has several medical uses but not widely explored in their pharmacological activities. Some peperomia plant been investigated reported have various activities, recently diabetes mellitus. This research was conducted screening phytochemical profile determine alpha-glucosidase inhibitor activities of five species that are easy grow cultivated Indonesia.
 Methods: Dried leaves were macerated with 70% ethanol vaporized by rotary evaporator. Phytochemical using qualitative chemical analysis inhibition p-nitrophenyl-α-D-glucopyranoside substrate, absorbance measured spectrophotometer UV-Vis.
 Results: The the extracts demonstrated presence secondary metabolites, such flavonoids, phenol, tannins, quinone, alkaloids, saponins, steroids, triterpenoids. showed IC50 value extract P. obtusifolia, clusiifolia, caperata (green), (red), argyreia 2.90; 18.05; 21.46; 23.81; 48.70 µg/ml respectively.
 Conclusion: highest activity obtusifolia an 2.90 µg/ml. Further needed explore its potential antidiabetic.