Alpha-blocking potencies of antihypertensive agents (prazosin, terazosin, bunazosin, SGB-1534 and ketanserin) having with quinazoline or quinazolinedione as assessed by radioligand binding assay methods in rat brain.
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چکیده
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Calcium channel blocking properties of SM-6586 in rat heart and brain as assessed by radioligand binding assay.
The interaction of SM-6586 (methyl 1,4-dihydro-2,6-dimethyl-3-[3-(N-benzyl-N-methyl-aminomethyl)-1,2,4- oxadiazolyl-5-yl]-4-(3-nitrophenyl)pyridine-5-carboxylate) with the specific binding of 3H-PN200-110 to rat heart and brain membranes was characterized and compared with those of other Ca2+ antagonists. The blockade of 3H-PN200-110 binding sites induced by nifedipine, nitrendipine and nimodip...
متن کاملRadioresponse of human lymphocytes pretreated with boron and gadolinium as assessed by the comet assay
Background: Boron and gadolinium are among the nuclides that hold a unique property of being a neutron capture therapy agent. Neutron beams have often a considerable portion of gamma rays with fast neutrons. Gamma rays, as beam contaminants, can cause considerable damage to normal tissues even if such tissues do contain high boron concentrations. Materials and Methods: The modification of radio...
متن کاملAlpha1-adrenoceptor subtypes on rat afferent arterioles assessed by radioligand binding and RT-PCR.
We utilized [3H]prazosin saturation and competition radioligand binding studies to characterize the expression of alpha1-adrenoceptors in preglomerular vessels. mRNA for adrenoceptor subtypes was assayed using RT-PCR. The vessels were isolated using an iron oxide-sieving method. [3H]prazosin bound to a single class of binding sites (Kd 0.087 +/- 0.012 nM, Bmax 326 +/- 56 fmol/mg protein). Phent...
متن کاملa1-Adrenoceptor subtypes on rat afferent arterioles assessed by radioligand binding and RT-PCR
Salomonsson, Max, Melinda Oker, Susan Kim, Hua Zhang, James E. Faber, and William J. Arendshorst. a1-Adrenoceptor subtypes on rat afferent arterioles assessed by radioligand binding and RT-PCR. Am J Physiol Renal Physiol 281: F172–F178, 2001.—We utilized [3H]prazosin saturation and competition radioligand binding studies to characterize the expression of a1-adrenoceptors in preglomerular vessel...
متن کاملOptimum Conditions of Radioligand Receptor Binding Assay of Ligands of Benzodiazepine Receptors
To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1989
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.12.170