.ALPHA.-Adrenoceptor blocking action of terazosin.

Pharmacological properties of beta-adrenoceptor blocking drugs

THE SELECTIVE ACTION OF /B-ADRENOCEPTOR BLOCKING DRUGS AND THE NATURE OF /3l and /2 ADRENOCEPTORS

1 Purified membranes retaining a catecholamine responsive adenylate cyclase have been prepared from rabbit heart, lung and (pseudo-pregnant) uterus. 2 These preparations have the characteristics of plasma membranes and both heart and lung respond to P-adrenoceptor agonists in the order: (± )-isoprenaline > (-)-noradrenaline > (-)-adrenaline > ( + )-isoprenaline > salbutamol. The sensitivity of ...

Action of several -adrenoceptor blocking drugs in the pregnant sheep and foetus.

1. The effect of several beta-adrenoceptor blocking drugs on the pregnant ewe and foetus were studied. Bunolol, butidrine, oxprenolol, propranolol and USVP65-24 all crossed the ovine placenta and produced a beta-adrenoceptor blockade in the ovine foetus. AH3474, AY21011 and sotalol did not cross the ovine placenta as assessed by the absence of a beta-blockade in the foetus when these compounds ...

Alpha-adrenoceptor blocking drugs and female urinary incontinence: prevalence and reversibility.

There have been occasional reports of female stress incontinence related to prazosin therapy for hypertension. This drug is now rarely used but recently longer acting alpha-adrenoceptor blocking drugs have been introduced. We have, therefore, investigated the prevalence of urinary incontinence in all our female patients who were receiving alpha-adrenoceptor blockers in comparison with women, ma...

Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists.

We investigated the relevance of selectivity for a given alpha-1-adrenoceptor subtype for in vivo uroselectivity of several alpha-1-adrenoceptor antagonists (alfuzosin, doxazosin, prazosin, tamsulosin, terazosin and 5-Me-urapidil). Comparison of the affinities of these alpha-1-adrenoceptor antagonists at the cloned alpha-1a, alpha-1b and alpha-1d-adrenoceptor subtypes revealed that tamsulosin a...