alpha 1 Antitrypsin (PI) allotypes in rheumatoid arthritis.

Alpha-i -antitrypsin associated liver disease in rheumatoid arthritis

Two cases of alpha-l-antitrypsin associated liver disease occurring in patients with rheumatoid arthritis are described. Both presented with abnormal liver function tests and the true diagnosis was only apparent after liver biopsy and detailed serological studies. The concurrence of these two conditions is noteworthy because of the postulated role of proteolytic enzymes in producing the charact...

Allele frequencies of alpha-1-antitrypsin (PI) in the Balkans.

The phenotype and allele frequencies of alpha-1-antitrypsin has been studied by an IEF technique (pH 4.2-4.9) in ten population samples from the Balkans. The allele frequencies varied from 0.6667 to 0.7361 (*M1), 0.1100 to 0.1793 (*M2), 0.0992 to 0.1700 (*M3), 0 to 0.0105 (*S), 0 to 0.0078 (*Z) and 0 to 0.0172 (others). The results were compared with data from South and Middle European populati...

Alpha 1-antitrypsin Pi types in COPD patients.

Changes in Glycosylation of Alpha-1-Protease Inhibitor in Inflammation (Rheumatoid Arthritis and Crohn\'s Disease)

Alpha-1-proteinase inhibitor (API) is one of the acute phase proteins. Following an inflammatory stimuli the concentration of API increased up to four folds. Accompanying these quantitative changes, there is qualitative alterations in the structure of carbohydrate moiety (glycosylation). To determine the alterations in the glycosylation of API in inflammation, API was isolated from the sera of...

Does the PI polymorphism alone control alpha-1-antitrypsin expression?

Whether genetic factors other than the protease-inhibitor (PI) polymorphism itself contribute to variation in alpha-1-antitrypsin is of both theoretical and practical interest. We have measured the quantity of alpha-1-antitrypsin (by an immunoturbidometric assay) and its activity (by assaying elastase inhibitory capacity [EIC]) in 583 individuals from 114 twin kinships who were also typed for P...