Allosteric modulation of GABAA receptors by extracellular ATP
نویسندگان
چکیده
منابع مشابه
Allosteric Modulation of αβδ GABAA Receptors
GABAA receptors mediate the majority of the fast inhibition in the mature brain and play an important role in the pathogenesis of many neurological and psychiatric disorders. The αβδ GABAA receptor localizes extraor perisynaptically and mediates GABAergic tonic inhibition. Compared with synaptically localized αβγ receptors, αβδ receptors are more sensitive to GABA, display relatively slower des...
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The importance of communication between neuronal and glial cells for brain function is recognized by a modern concept of 'tripartite synapse'. Astrocytes enwrap synapses and can modulate their activity by releasing gliotransmitters such as ATP, glutamate and D-serine. One of the regulatory pathways in the tripartite synapse is mediated by P2X purinoreceptors. Release of ATP from synaptic termin...
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ژورنال
عنوان ژورنال: Molecular Brain
سال: 2014
ISSN: 1756-6606
DOI: 10.1186/1756-6606-7-6