Allopregnanolone involvement in feeding regulation, overeating and obesity
نویسندگان
چکیده
منابع مشابه
Allopregnanolone involvement in feeding regulation, overeating and obesity
Obesity is strongly associated with ill health, primarily caused by consumption of excessive calories, and promoted (inter alia) by gamma-amino-butyric-acid (GABA) stimulating food intake by activating GABAA receptors (primarily with α3 and α2 subunits) in the hypothalamic arcuate nucleus and paraventricular nucleus. Allopregnanolone is a potent positive GABAA receptor modulating steroid (GAMS)...
متن کاملUnderstanding overeating and obesity.
The combination of economic and biological factors is likely to result in overeating in the current environment of cheap and readily available food. This propensity is shown using a "dual decision" approach where choices reflect the interaction of a "deliberative" system, operating as in standard economic models, and an "affective" system that responds rapidly to stimuli without considering lon...
متن کاملInvolvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity.
Histamine H(1) receptors (H(1)-Rs) are found in peripheral tissues and in regions of the hypothalamus that are concerned with regulating body composition. In the present study, we investigated the detailed mechanisms of histamine H(1)-Rs in the development of obesity. Histamine H(1)-R knockout (H1KO) mice gradually developed mature-onset obesity, which was accompanied by hyperphagia and decreas...
متن کاملAllopregnanolone effects on food intake and weight gain
Background Obesity is currently one of the major causes of ill health and it is clear that overeating is the cause of obesity. However, the actions of many endogenous factors that contribute to overeating are still not well understood. Gamma-aminobutyric acid (GABA)-ergic transmission has been shown to be of great importance for food intake regulation. The progesterone metabolite allopregnanolo...
متن کاملHigh glycemic index foods, overeating, and obesity.
OBJECTIVE The prevalence of obesity has increased dramatically in recent years. However, the role of dietary composition in body weight regulation remains unclear. The purpose of this work was to investigate the acute effects of dietary glycemic index (GI) on energy metabolism and voluntary food intake in obese subjects. METHODS Twelve obese teenage boys were evaluated on three separate occas...
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ژورنال
عنوان ژورنال: Frontiers in Neuroendocrinology
سال: 2018
ISSN: 0091-3022
DOI: 10.1016/j.yfrne.2017.07.002