Allograft and Xenograft Acceptance under FK-506 and Other Immunosuppressant Treatment
نویسندگان
چکیده
منابع مشابه
Allograft and xenograft acceptance under FK-506 and other immunosuppressant treatment.
In June 1992 we published what is a new definition of graft acceptance. I Within a few minutes after the transplantation of any whole organ (as in the intestine) (FIG. 1), a brisk two-way cell traffic starts in which dendritic and lymphoid cells from the recipient move into and become an integral part of the graft. With effective immunosuppression, the result in the intestine is the formation o...
متن کاملFK 506--an effective immunosuppressant in achieving long-term functional islet allograft survival in diabetic rats.
TRANSPLANTED pancreatic islet tissue has been shown to restore normoglycemia and prevent the development of chronic complications in diabetic animals. 1 The application of alloand xenotransplantation of pancreatic islets for the treatment of diabetes is hindered by immune rejection. FK 506, a new immunosuppressive agent, has been demonstrated to be effective in the prolongation of survival of h...
متن کاملFK 506: an effective immunosuppressant for islet xenotransplantation.
R EPLACING the damaged insulin-producing tissue by transplantation of pancreatic islets is considered the most physiological approach to diabetes treatment and has the potential to prevent the development of chronic complications. Due to the large number of potential diabetic recipients. it would be impossible to obtain sufficient supply of donor organs to fulfill the demands. One solution to r...
متن کاملKidney transplantation under FK 506.
The experimental immunosuppressive drug FK 506 was given to 36 renal transplant recipients, many of whom were highly sensitized. Ten were undergoing kidney retransplantation, 10 also underwent liver transplantation at an earlier time (6 patients) or concomitantly (4 patients), and 2 patients received a third organ (heart or pancreas) in addition to a liver and kidney. With follow-ups of 4 to 13...
متن کاملFK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.
The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We proceeded to test the effect of the agent on various in vitro immune systems. It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 (IL-2), interleukin 3 and gamma-interferon and...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 1993
ISSN: 0077-8923,1749-6632
DOI: 10.1111/j.1749-6632.1993.tb35849.x