منابع مشابه
Models and mechanisms of hyperalgesia and allodynia.
Hyperalgesia and allodynia are frequent symptoms of disease and may be useful adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in their own right. Considerable progress has been made in developing clinically relevant animal models for identifying the most significant underlying mechanisms. This review deals with experimental models that are currently used to...
متن کاملContralateral hyperalgesia and allodynia following intradermal capsaicin injection in man
OBJECTIVES Contralateral responses to unilateral stimuli have been well described in animal models. These range from central sensitization to peripheral inflammatory responses. Our aim was to test for contralateral responses following unilateral intradermal capsaicin injection in man. METHODS Three groups were investigated. A healthy volunteer group (1) was injected with capsaicin into the vo...
متن کاملEffect of acute caffeine administration on hyperalgesia and allodynia in a rat neuropathic pain model
Introduction: Damage to the central and peripheral nervous system causes neuropathic pain. Caffeine is a plant alkaloid and non-selective antagonist of A1, A2a and A2b adenosine receptors. It is reported that caffeine increases the threshold of pain. In this study, the effect of acute caffeine on behavioral responses of neuropathic pain was investigated. Materials and Methods: The present study...
متن کاملMicroinfusion of TNFα and its antibody into locus coeruleus modifies nerve injury induced thermal hyperalgesia and mechanical allodynia
Introduction: Glial activation and secretion of cytokines at the spinal level is known as part of chronic pain pathogenesis. Although changes in TNFα at the supraspinal level are reported during chronic pain, its exact role and site of action remain to be elucidated. We investigated the effect of microinfusion of TNFα into the LC in a rat model of neuropathic pain. Methods: Male Wistar rats...
متن کاملLumbar sympathectomy attenuates cold allodynia but not mechanical allodynia and hyperalgesia in rats with spared nerve injury.
UNLABELLED In certain patients with neuropathic pain, the pain is dependent on activity in the sympathetic nervous system. To investigate whether the spared nerve injury model (SNI) produced by injury to the tibial and common peroneal nerves and leaving the sural nerve intact is a model for sympathetically maintained pain, we measured the effects of surgical sympathectomy on the resulting mecha...
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ژورنال
عنوان ژورنال: Pain medicine
سال: 2018
ISSN: 2519-2752,2414-3812
DOI: 10.31636/pmjua.v3i2.98