Allelopathic Studies on Milk Thistle (Silybum marianum)

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Milk Thistle (Silybum marianum)

Milk thistle is a well known and commonly used herb, used particularly in hepatic diseases. It has very potent antioxidant, anti-inflammatory, and antifibrotic properties (1). As a single agent its therapeutic effects in liver disease appear to be modest (2,3,4,5). Herbal medicines and supplements are likely to be much more beneficial when used synergistically in combinations or formulas. Milk ...

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Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan.

PURPOSE Milk thistle (Silybum marianum) is one of the most commonly used herbal therapies, and its principal constituent silybin significantly inhibits cytochrome P450 isoform 3A4 (CYP3A4) and UDP glucuronosyltransferase isoform 1A1 (UGT1A1) in vitro. Here, we investigated whether milk thistle affects the pharmacokinetics of irinotecan, a substrate for CYP3A4 and UGT1A1, in humans. EXPERIMENT...

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Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.

The biochemical influence of flavonolignans from the milk thistle Silybum marianum has been tested on kidney cells of African green monkeys. Two nonmalignant cell lines were selected, with the focus of the work on the fibroblast-like Vero line. Proliferation rate, biosynthesis of protein and DNA, and the activity of the enzyme lactate dehydrogenase (as a measure of the cellular metabolic activi...

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allelopathic effects of sorghum on milk thistle (silybum marianum l.) seed germination and growth

abstract     crop residues are well known for their chemical (allelopathic) effects on crops. the allelopathic potential of the aqueous extracts and chopped residual of sorghum (sorghum bicolor l.) on germination, seedling growth, relative water content, seedling dry weight, seedling length and antioxidant enzyme activity namely catalase (cat), peroxidase (pod) and superoxide dismutase (sod) of...

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Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism.

Milk thistle (Silybum marianum) is a medicinal plant that has been used for thousands of years as a remedy for a variety of ailments. The main component of S. marianum fruit extract (silymarin) is a flavonolignan called silybin, which is not only the major silymarin element but is also the most active ingredient of this extract, which has been confirmed in various studies. This compound belongs...

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ژورنال

عنوان ژورنال: International Journal of Agricultural Research, Innovation and Technology

سال: 2013

ISSN: 2224-0616

DOI: 10.3329/ijarit.v2i1.14007