Allele-specific relative telomere lengths are inherited
نویسندگان
چکیده
منابع مشابه
Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer
Telomeric dysfunction is linked to colorectal cancer (CRC) initiation. However, the relationship of normal tissue and tumor telomere lengths with CRC progression, molecular features and prognosis is unclear. Here, we measured relative telomere length (RTL) by real-time quantitative PCR in 90 adenomas (aRTL), 419 stage I-IV CRCs (cRTL) and adjacent normal mucosa (nRTL). Age-adjusted RTL was anal...
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Chronic myeloid leukemia (CML) is a neoplasia characterized by proliferation of a myeloid cell lineage and chromosome translocation t(9;22) (q34;q11.2). As in the case of most cancers, the average telomere length in CML cells is shorter than that in normal blood cells. However, there are currently no data available concerning specific individual telomere length in CML. Here, we studied telomere...
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The aim of this study was to determine whether there is an association between leukocyte telomere length (LTL), and estrogen level, oxidative stress, cardiovascular disease (CVD) risk factors, and cardiorespiratory fitness (CRF) in pre- and postmenopausal obese women. Fifty-four obese women (premenopausal, n=25; postmenopausal, n=29) were selected to participate in this study. The outcome measu...
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D breeding must be one of the oldest uses of genetics. Ever since the domestic dog (Canis familaris) evolved from the gray wolf (Canis lupus), humans have been changing the genetics of our best friend. The original shift from wild to domesticated probably came when friendly wolves hung around campfires, scrounging for scraps. Perhaps the protodogs made themselves useful by chasing away other sc...
متن کاملTelomere capping proteins are structurally related to RPA with an additional telomere-specific domain.
Telomeres must be capped to preserve chromosomal stability. The conserved Stn1 and Ten1 proteins are required for proper capping of the telomere, although the mechanistic details of how they contribute to telomere maintenance are unclear. Here, we report the crystal structures of the C-terminal domain of the Saccharomyces cerevisiae Stn1 and the Schizosaccharomyces pombe Ten1 proteins. These st...
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ژورنال
عنوان ژورنال: Human Genetics
سال: 2006
ISSN: 0340-6717,1432-1203
DOI: 10.1007/s00439-006-0158-5