Allele-specific locus binding and genome editing by CRISPR at the p16INK4a locus
نویسندگان
چکیده
منابع مشابه
Allele-specific locus binding and genome editing by CRISPR at the p16INK4a locus
The clustered regularly interspaced short palindromic repeats (CRISPR) system has been adopted for a wide range of biological applications including genome editing. In some cases, dissection of genome functions requires allele-specific genome editing, but the use of CRISPR for this purpose has not been studied in detail. In this study, using the p16INK4a gene in HCT116 as a model locus, we inve...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep30485