Alkaloid, Phenolic Profiling and Biological Activities of Caralluma russeliana Methanol Extracts from Al Baha region, Saudi Arabia

The current work highlights the antioxidant, cytotoxicity and antimicrobial activities of methanol extract Caralluma russeliana their alkaloids phenolics composition by HPLC analysis. antioxidant activity C. displayed that it quenched DPPH with IC50 119.17 μg/ml, ABTS 155.71 NO 223.40 μg/ml H2O2 184.40 μg/ml. Among tested cell lines, hepatocellular (HepG2) lung (A549) were most sensitive lines towards which significantly block proliferation 24.37 μg/mL 26.84 μg/mL, respectively, moderately active against HCT-116, skin A-431 prostate PC-3 cells. Furthermore, was bacterial strains inactive fungal showed MIC 3300 1666.66 S. aureus P. vulgaris, respectively in assay. identified phenolic constituents such as berberine, camptothecin, chlorogenic acid, syringic p-coumaric catechol cycloclavine are known to exert anticancer effect triggered oxidative stress through different mechanisms.