Alkaline phosphatase activity of glutaraldehyde-treated bovine pericardium used in bioprosthetic cardiac valves.
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چکیده
منابع مشابه
Alkaline phosphatase activity of glutaraldehyde-treated bovine pericardium used in bioprosthetic cardiac valves.
Bioprosthetic valves fail frequently because of pathological mineralization, a process that begins in cell remnants of the glutaraldehyde (GLUT) fixed tissue. Other pathological cardiovascular calcification and physiological mineralization in skeletal/dental tissues are both largely initiated in cell-derived membranous structures (often called "matrix vesicles"), and the enzyme alkaline phospha...
متن کاملObservations on glutaraldehyde-treated heterologous cardiac valves.
Recent publications on commercial porcine bioprosthetic cardiac valves have stated that the endothelium disappears during the glutaraldehyde processing and that in many cases histological evidence of early tissue deterioration was found. Our experiences have shown that porcine aortic valves can be processed in glutaraldehyde without loss of the integrity of the endothelium and with the developm...
متن کاملInitiation of mineralization in bioprosthetic heart valves: studies of alkaline phosphatase activity and its inhibition by AlCl3 or FeCl3 preincubations.
The principal cause of the clinical failure of bioprosthetic heart valves fabricated from glutaraldehyde-pretreated porcine aortic valves is calcification. Other prostheses composed of tissue-derived and polymeric biomaterials also are complicated by deposition of mineral. We have previously demonstrated that: (a) Failure due to calcification of clinical bioprosthetic valves can be simulated by...
متن کاملBovine pericardium retail preserved in glutaraldehyde and used as a vascular patch
BACKGROUND In this study we evaluated the performance of bovine pericardium preserved in glutaraldehyde used as a vascular patch. METHODS Fourteen young pigs, six females and eight males, weighting 10.3 - 18.4 kg were used in our study. We implanted three remnants in each pig, two in the abdominal aorta and one was juxtaposed to the peritoneum. The smooth face (SF) and rough face (RF) of each...
متن کاملEffect of freeze-drying on the mechanical, physical and morphological properties of glutaraldehyde-treated bovine pericardium: evaluation of freeze-dried treated bovine pericardium properties.
PURPOSE Biomaterials have been widely used in the field of regenerative medicine. Bovine pericardium tissue has been successfully used as a bioprosthetic material in manufacturing heart valves, but studies concerning the tissue are ongoing in order to improve its storage, preservation and transportation. This article provides an overview of the characteristics of bovine pericardium tissue chemi...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1988
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.63.4.844