ALK Fusion Protein Expression in Lung Adenocarcinoma and its Correlation with EGFR Protein Expression

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

p53 Protein Expression and Its Relation to the Apoptotic Index in Prostate Adenocarcinoma

Background: Prostate cancer is one of the most commonly diagnosed cancers in males. Tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. Objective: To investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. Methods: In this study expression of p53 was examined in p...

متن کامل

Mycobacterium tuberculosis HspX/EsxS Fusion Protein: Gene Cloning, Protein Expression, and Purification in Escherichia coli

Background: The purpose of this study was to clone, express, and purify a novel multidomain fusion protein of Micobacterium tuberculosis (Mtb) in a prokaryotic system. Methods: An hspX/esxS gene construct was synthesized and ligated into a pGH plasmid, E. coli TOP10 cells were transformed, and the vector was purified. The vector containing the construct and pET-21b (+) plasmid were digested ...

متن کامل

MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status

Lung adenocarcinoma has distinctive clinicopathological features that are related to specific genetic alterations, including EGFR and KRAS mutations and ALK rearrangement. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate many important biological processes and influence cancer phenotypes. This study retrospectively investigated microRNA expression profiles, and their cli...

متن کامل

SEC31A-ALK Fusion Gene in Lung Adenocarcinoma

Anaplastic lymphoma kinase (ALK) fusion is a common mechanism underlying pathogenesis of non-small cell lung carcinoma (NSCLC) where these rearrangements represent important diagnostic and therapeutic targets. In this study, we found a new ALK fusion gene, SEC31A-ALK, in lung carcinoma from a 53-year-old Korean man. The conjoined region in the fusion transcript was generated by the fusion of SE...

متن کامل

Pre-Treatment Serum CEA and EGFR Mutations and EML4-ALK Fusion Gene in Lung Adenocarcinoma

Lung cancer is the most common cause of cancerrelated deaths, where it is associated with a 5-year worldwide survival rate of less than 15% (Jemal et al., 2011). Among new diagnoses of pulmonary carcinoma, Non-small-cell lung cancer (NSCLC) accounts for approximately 80% (Ozgul et al., 2013). Despite great efforts to improve the survival of patients with NSCLC, the outcomes are still considered...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Madridge Journal of Oncogenesis

سال: 2018

ISSN: 2641-5267

DOI: 10.18689/mjo-1000109