منابع مشابه
Aldosterone-Producing Adenomas
Unilateral primary aldosteronism (PA) is a common surgically curable cause of secondary hypertension. Adrenal glands removed for unilateral PA display histological heterogeneity. Recently, gain-of-function somatic mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D, and CTNNB1 have been found in 50% to 80% of aldosterone-producing adenomas (APAs). These gain-of-function mutations provide plausible mech...
متن کاملGenetic Alterations and Molecular Signatures in Aldosterone Producing Adenomas
Åkerström, T. 2016. Genetic Alterations and Molecular Signatures in Aldosterone Producing Adenomas. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1197. 49 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9517-6. Primary Aldosteronism (PA) is caused by autonomous overproduction of aldosterone. Aldosterone is necessary for fluid and ion homeosta...
متن کامل19-Nor-deoxycorticosterone production from aldosterone-producing adenomas.
19-Nor-deoxycorticosterone (19-nor-DOC), a hypertensinogenic mineralocorticoid, equipotent with aldosterone and independent of the renin-angiotensin system, is synthesized in the kidney and excreted in excess in the urine of patients with aldosterone-producing adenomas. This current study evaluated the adrenal and renal venous levels of aldosterone and 19-nor-DOC after adrenal and renal venous ...
متن کاملLocalization of the endothelin system in aldosterone-producing adenomas.
Endothelin-1 (ET-1) could play a role in the regulation of aldosterone secretion of the human adrenal gland. The presence of the endothelin-converting enzyme 1 (ECE-1) and ET-1 suggests that there is a local ET system in the adrenal cortex, but the in situ synthesis of ET-1 remains to be confirmed. The cellular distribution of the whole ET system was evaluated in 20 cases of aldosterone-produci...
متن کامل[A case of bilateral aldosterone-producing adrenal adenomas].
A 43-year-old female was admitted to our hospital for high blood pressure control. She showed hypokalemia with increased urinary potassium excretion, high plasma aldosterone concentration (33.9ng/dl, normal range; 2-12ng/dl) and reduced plasma renin activity (trace, normal range; 0.83-5ng/ml/hr). Bilateral adrenal tumors were revealed by abdominal computed tomography, and left adrenalectomy and...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2017
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.117.09057