Aldose Reductase Gene Polymorphisms and Diabetic Retinopathy Susceptibility
نویسندگان
چکیده
منابع مشابه
Aldose Reductase Gene Polymorphisms and Diabetic Retinopathy Susceptibility
OBJECTIVE Aldose reductase (ALR) is involved in diabetic microvascular damage via the polyol pathway. A recent meta-analysis found genetic variation in the ALR gene (AKR1B1) to be significantly associated with diabetic retinopathy (DR). We investigated the genetic association of AKR1B1 with DR. RESEARCH DESIGN AND METHODS The study enrolled 909 individuals with diabetes. Participants were gen...
متن کاملPolymorphisms of the aldose reductase gene and susceptibility to retinopathy in type 1 diabetes mellitus.
PURPOSE Aldose reductase (ALR2) is the first and rate-limiting enzyme of the polyol pathway and is involved in the pathogenesis of diabetic retinopathy. Polymorphisms of the ALR2 gene are associated with susceptibility to diabetic retinopathy in Chinese and Japanese patients with type 2 diabetes. There are no reports investigating these polymorphisms in white patients with type 1 diabetes from ...
متن کاملCorrelation between erythrocyte aldose reductase level and human diabetic retinopathy.
AIM To examine the relation between aldose reductase (AR) and the development and progression of diabetic retinopathy by comparing the erythrocyte AR levels with the prevalence of diabetic retinopathy in NIDDM patients. METHODS A clinic based cross sectional study was used. 611 NIDDM patients and 73 controls were enrolled. Erythrocyte AR levels were determined by ELISA. These AR levels were t...
متن کاملErythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
PURPOSE Activation of polyol pathway due to increased aldose reductase (ALR2) activity has been implicated in the development of diabetic complications including diabetic retinopathy (DR), a leading cause of blindness. However, the relationship between hyperglycemia-induced activation of polyol pathway in retina and DR is still uncertain. We investigated the relationship between ALR2 levels and...
متن کاملEvaluation of AC(n) and C(-106)T polymorphisms of the aldose reductase gene in Brazilian patients with DM1 and susceptibility to diabetic retinopathy
PURPOSE Diabetic retinopathy (DR) is one of the most important microvascular complications in both type 1 and type 2 diabetes. In Brazil, its proliferative form is the second cause of irreversible blindness among adults of working age. Despite the strong association of DR with disease duration and degree of chronic hyperglycemia, genetic predisposition has been recognized as a possible trigger ...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2010
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc09-1893