منابع مشابه
Alcoholic Myopathy: Pathophysiologic Mechanisms and Clinical Implications
Skeletal muscle dysfunction (i.e., myopathy) is common in patients with alcohol use disorder. However, few clinical studies have elucidated the significance, mechanisms, and therapeutic options of alcohol-related myopathy. Preclinical studies indicate that alcohol adversely affects both anabolic and catabolic pathways of muscle-mass maintenance and that an increased proinflammatory and oxidativ...
متن کاملChronic alcoholic myopathy: transcription and translational alterations.
Alcoholic myopathy is characterized by selective atrophy of type II fibers and affected subjects lose up to 20% of the entire musculature. Between one- and two-thirds of all alcohol abusers are affected. In acute studies, defective rates of translation occur and type II fiber-predominant muscles are more adversely affected than type I fiber-predominant muscles. Furthermore, acetaldehyde is also...
متن کاملClinical and experimental skeletal muscle alcoholic myopathy.
Musculoskeletal symptoms are frequent in chronic alcohol abusers, but only relatively recently has a search been made for the pathological basis of these complaints. A prospective study of 150 unselected patients admitted with various forms of alcohol abuse, showed that on quadriceps muscle biopsy two-thirds of the patients had significant and specific atrophy of the type IIB (anaerobic, fast-t...
متن کاملHypomagnesaemia causing myopathy and hypocalcaemia in an alcoholic.
A well-nourished alcoholic patient developed a subacute myopathy which responded rapidly to correction of severe hypomagnesaemia. The finding of profound hypocalcaemia prompted the measurement of serum magnesium. Magnesium deficiency should be looked for in any alcoholic patient with a myopathy as the prognosis seems better than in many other forms of alcoholic myopathy. Correction of the magne...
متن کاملAlcoholic myopathy: vitamin D deficiency is related to muscle fibre atrophy in a murine model.
AIMS Chronic myopathy has been described in alcoholics, characterized by atrophy of type II fibres, and vitamin D deficiency. Low serum vitamin D levels are frequent in alcoholics. The possibility exists that serum vitamin D levels are related to muscle changes in a murine experimental model. METHODS Histological analysis of the right gastrocnemius muscle was performed in four groups of adult...
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ژورنال
عنوان ژورنال: BMJ
سال: 1969
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.4.5686.785