Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation
نویسندگان
چکیده
منابع مشابه
Early Maternal Alcohol Consumption Alters Hippocampal DNA Methylation, Gene Expression and Volume in a Mouse Model
The adverse effects of alcohol consumption during pregnancy are known, but the molecular events that lead to the phenotypic characteristics are unclear. To unravel the molecular mechanisms, we have used a mouse model of gestational ethanol exposure, which is based on maternal ad libitum ingestion of 10% (v/v) ethanol for the first 8 days of gestation (GD 0.5-8.5). Early neurulation takes place ...
متن کاملAlcohol exposure alters cell cycle and apoptotic events during early neurulation.
BACKGROUND Fetal alcohol exposure causes growth deficits, microencephaly, and neurological abnormalities. Although the effects of alcohol on developmental delay and growth-related deficits have been hypothesized, little is understood about how alcohol alters, in particular, the cyclin pathway within the cell cycle, which is critical to proliferation and apoptotic control. In this study, we exam...
متن کاملPharmacology and Cell Metabolism Alcohol Exposure Alters Cell Cycle and Apoptotic Events during Early Neurulation
Background: Fetal alcohol exposure causes growth deficits, microencephaly, and neurological abnormalities. Although the effects of alcohol on developmental delay and growth-related deficits have been hypothesized, little is understood about how alcohol alters, in particular, the cyclin pathway within the cell cycle, which is critical to proliferation and apoptotic control. In this study, we exa...
متن کاملCellular DNA methylation program during neurulation and its alteration by alcohol exposure.
BACKGROUND Epigenetic changes are believed to be among the earliest key regulators for cell fate and embryonic development. To support this premise, it is important to understand whether or not systemic epigenetic changes coordinate with the progression of development. We have demonstrated that DNA methylation is programmed when neural stem cells differentiate (Zhou et al.,2011). Here, we analy...
متن کاملCulture of mouse embryos during neurulation.
A comparison between static versus rotator culture systems and a variety of media (rat serum, new born calf serum, DMEM and Waymouth's) was made in an attempt to promote in vitro growth of mouse embryos from the beginning of neurulation (headfold stage) to the closure of the neural tube and formation of the limb buds (48 h). The results demonstrate that good development can be achieved for 48 h...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2009
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.4.7.9925