Alcohol-Disulfiram Reactions
نویسندگان
چکیده
منابع مشابه
Cefotetan-induced disulfiram-type reactions and hypoprothrombinemia.
A double-blind, placebo-controlled study in eight healthy male volunteers was conducted to study possible disulfiram-type reactions and hypoprothrombinemia associated with cefotetan administration. Three doses of cefotetan (2 g) or of placebo were administered at 12-h intervals. Ethanol (0.5 g/kg of total body weight) was ingested 1 h after the third dose. Blood ethanol, serum acetaldehyde, and...
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Ingestion of ethanol in the presence of disulfiram may cause a histamine-like reaction due to accumulation of acetaldehyde. These disulfiram-ethanol reactions (DERs) are manifested by hypotension, tachycardia, gastritis, and angioedema. Fomepizole, an inhibitor of alcohol dehydrogenase, may halt progression of this reaction by blocking ethanol metabolism to acetaldehyde. We present 2 cases of d...
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When taken in an adequate dose, disulfiram usually deters the drinking of alcohol by the threat or experience of an unpleasant reaction. However, unless its consumption is carefully supervised by a third party as part of the formal or im-plied therapeutic contract, it is usually discontinued and the deterrent effect is therefore lost. In most studies, disulfiram administration has not been supe...
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was the purpose of our double-blind, placebo-controlled study to verify the efficacy of cyanamide in the treatment of adolescent alcohol abusers (Niederhofer et al., 2003). Cyanamide is registered for the treatment of alcohol misusers; we therefore thought it would be appropriate to ascertain its efficacy, and in particular its safety, in adolescents. Disulfiram 442 The Randomised Controlled Tr...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1984
ISSN: 0007-1250,1472-1465
DOI: 10.1192/s0007125000203541