منابع مشابه
Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardium.
Cardioplegic arrest for bypass surgery imposes global ischemia on the myocardium, which generates oxyradicals and depletes myocardial high-energy phosphates. The glycolytic metabolite pyruvate, but not its reduced congener lactate, increases phosphorylation potential and detoxifies oxyradicals in ischemic and postischemic myocardium. This study tested the hypothesis that pyruvate mitigates oxid...
متن کاملNicorandil cardioplegia or procaine cardioplegia?
I read with interest the article by Steensrud and colleagues on myocardial protection with nicorandil cardioplegia [1]. The study investigates the protective efficacy of intermittent cold blood nicorandil cardioplegia compared with intermittent standard hyperkalemic cold blood and cold crystalloid cardioplegia in pigs undergoing cardiopulmonary bypass and hearts subjected to 60 min global ische...
متن کاملPyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass.
Pyruvate-fortified cardioplegia protects myocardium and hastens postsurgical recovery of patients undergoing cardiopulmonary bypass (CPB). Pyruvate reportedly suppresses degradation of the alpha-subunit of hypoxia-inducible factor-1 (HIF-1), an activator of the gene encoding the cardioprotective cytokine erythropoietin (EPO). This study tested the hypothesis that pyruvate-enriched cardioplegia ...
متن کاملThe effect of acetate, pyruvate, and glucose on alcohol metabolism.
Although many investigators have studied the effects of pyruvate and glucose on alcohol metabolism, there is still disagreement as to what effect. they have on the rate of alcohol oxidat.ion. Jacobsen (1) discussed t.he various reports in which the results vary from no effect of pyruvate, inhibition by pyruvate or glucose, or an actual increase in the rate of alcohol oxidation by pyruvate or gl...
متن کاملPreconditioning and Potassium Cardioplegia
J Thorac Cardiovasc Surg Ninomiya, Motohiko Osako and Hiroji Imamura Kejie Lu, Hajime Otani, Tadashi Yamamura, Yoshihisa Nakao, Reiji Hattori, Hideki preconditioning and potassium cardioplegia Protein kinase C isoform–dependent myocardial protection by ischemic http://jtcs.ctsnetjournals.org/cgi/content/full/121/1/0137 the World Wide Web at: The online version of this article, along with update...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1991
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)36735-2