Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness
نویسندگان
چکیده
منابع مشابه
How Old are Your Arteries? Exercise‐Mediated Protection From Age‐Associated Vascular Stiffness
A s we age, the blood vessel becomes more susceptible to pathologies including hypertension and atherosclerosis. A famous saying of Thomas Sydenham, English physician, states: “man is as old as his arteries.” However, changes in the function and structure of the arteries with aging, such as arterial stiffening and thickening, do not occur to the same extent in all people. Studies by Seals et al...
متن کاملAge and gender affect ventricular-vascular coupling during aerobic exercise.
OBJECTIVES The goal of this study was to examine the age-associated differences in ventricular-vascular coupling, defined by the ratio of arterial elastance (EaI) to left ventricular systolic elastance (E(LV)I), and its components, at rest and during exercise. BACKGROUND Ejection fraction (EF) increases during exercise, but the EF reserve decreases with aging. Ejection fraction is inversely r...
متن کاملExercise, Vascular Stiffness, and Tissue Transglutaminase
BACKGROUND Vascular aging is closely associated with increased vascular stiffness. It has recently been demonstrated that decreased nitric oxide (NO)-induced S-nitrosylation of tissue transglutaminase (TG2) contributes to age-related vascular stiffness. In the current study, we tested the hypothesis that exercise restores NO signaling and attenuates vascular stiffness by decreasing TG2 activity...
متن کاملLeft Ventricular Torsion Associated With Aortic Stiffness in Hypertension
BACKGROUND Left ventricular (LV) torsion plays a key role in cardiac efficiency. In hypertension, aortic stiffening augments cardiac afterload. However, little is known about the links between LV regional contraction and aortic stiffness. We, therefore, investigated these relationships and their contribution to LV diastolic function. METHODS AND RESULTS The study included normotensive and hyp...
متن کاملMetabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness.
OBJECTIVES We sought to evaluate whether the clustering of multiple components of the metabolic syndrome (MS) has a greater impact on these vascular parameters than individual components of MS. BACKGROUND Intima-media thickness (IMT) and vascular stiffness have been shown to be independent predictors of adverse cardiovascular events. The MS is defined as the clustering of three or more of the...
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ژورنال
عنوان ژورنال: Experimental Gerontology
سال: 2012
ISSN: 0531-5565
DOI: 10.1016/j.exger.2012.04.006