Airway inflammation and mannitol challenge test in COPD
نویسندگان
چکیده
منابع مشابه
Airway inflammation and mannitol challenge test in COPD
BACKGROUND Eosinophilic airway inflammation has successfully been used to tailor anti-inflammatory therapy in chronic obstructive pulmonary disease (COPD). Airway hyperresponsiveness (AHR) by indirect challenges is associated with airway inflammation. We hypothesized that AHR to inhaled mannitol captures eosinophilia in induced sputum in COPD. METHODS Twenty-eight patients (age 58 ± 7.8 yr, p...
متن کاملAirway Inflammation in COPD*
Inflammation of the airways has been regarded as a cardinal pathophysiologic feature of asthma for some 20 years. This concept has been based on evidence from a variety of sources: the histologic changes in the airway wall, hyperresponsiveness of the asthmatic airways to a wide range of natural and pharmacologic agents, the presence of activated inflammatory and immune cells and their mediators...
متن کاملEosinophilic airway inflammation in COPD
Chronic obstructive pulmonary disease is a common condition and a major cause of mortality. COPD is characterized by irreversible airflow obstruction. The physiological abnormalities observed in COPD are due to a combination of emphysema and obliteration of the small airways in association with airway inflammation. The predominant cells involved in this inflammatory response are CD8+ lymphocyte...
متن کاملBronchial hyperresponsiveness to mannitol, airway inflammation and Asthma Control Test in atopic asthmatic children
INTRODUCTION The aim of this study was to evaluate the relationship between airway hyperresponsiveness (AHR) to mannitol and bronchial inflammation measured as exhaled nitric oxide (FeNO) and to assess whether asthma control correlates with AHR to mannitol and FeNO in atopic asthmatic children. MATERIAL AND METHODS Allergy evaluation, the mannitol challenge test, FeNO levels and the Asthma Co...
متن کاملThe Relationship between the Severity of Airway Obstruction and COPD Diagnostic Questionnaire Score in COPD Patients
Background & objectives: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and systemic inflammation which is also associated with pulmonary and extra-pulmonary complications. COPD Diagnostic Questionnaire (CDQ) is a valid questionnaire that is used to identify patients with COPD. The purpose of this study was to determine the relationship between ...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2011
ISSN: 1465-993X
DOI: 10.1186/1465-9921-12-11