AIFM2 (apoptosis-inducing factor, mitochondrion-associated, 2)

Apoptosis-inducing factor

Although the seminal paper by Kerr, Wyllie and Currie (Kerr et al., 1972), who coined the word ‘apoptosis’, stated that only nuclei but not cytoplasmic organelles would undergo major modifications in the dying cell, recent evidence suggests that no cellular compartment is spared (Ferri and Kroemer, 2001). Mitochondria are particularly affected early during the apoptotic process, and they are no...

Apoptosis-Inducing Factor Regulates Death

vital functions of apoptosis inducing factor (aif)

in many models of programmed cell death, the mitochondrial protein aif translocates to the nucleus, where it induces the chromatin condensation and dna degradation. however, today it is well established that this flavoprotein is bifunctional. in addition to its lethal function in the nucleus of dying cells, aif plays a vital bioenergetic role in healthy ones by regulating mainly the activity of...

Vital functions of Apoptosis Inducing Factor (AIF)

In many models of programmed cell death, the mitochondrial protein AIF translocates to the nucleus, where it induces the chromatin condensation and DNA degradation. However, today it is well established that this flavoprotein is bifunctional. In addition to its lethal function in the nucleus of dying cells, AIF plays a vital bioenergetic role in healthy ones by regulating mainly the activity of...

SIVA 1 ( SIVA 1 , Apoptosis - Inducing Factor )

Review on SIVA1, with data on DNA/RNA, on the protein encoded and where the gene is implicated.