AgRP neurons: a switch between peripheral carbohydrate and lipid utilization
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چکیده
منابع مشابه
AgRP neurons: a switch between peripheral carbohydrate and lipid utilization.
AgRP/NPY neurons are critical regulators of body weight and food intake. Concordant with their orexigenic effects, it is expected that AgRP ablation leads to the appearance of a lean phenotype. In the current issue of The EMBO Journal, Joly-Amado et al (2012) describe an obese phenotype in a model of AgRP-ablated mice, and link it to a shift in metabolic profile in efferent tissues such as the ...
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Obesity-related diseases such as diabetes and dyslipidemia result from metabolic alterations including the defective conversion, storage and utilization of nutrients, but the central mechanisms that regulate this process of nutrient partitioning remain elusive. As positive regulators of feeding behaviour, agouti-related protein (AgRP) producing neurons are indispensible for the hypothalamic int...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2012
ISSN: 0261-4189
DOI: 10.1038/emboj.2012.287