Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinsons Disease
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چکیده
منابع مشابه
Role of peroxisome proliferator-activated receptor alpha and gamma in antiangiogenic effect of pomegranate peel extract
Objective(s): Herbal medicines are promising cancer preventive candidates. It has been shown that Punica granatum L. could inhibit angiogenesis and tumor invasion. In this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (PPE) is partly attributable to Peroxisome proliferator-activated receptors (PPARs) activation in the Human Umbilical Vein Endothelial Cell...
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Single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor gamma (PPARG) gene have been associated with cardiovascular risk factors, particularly obesity and diabetes. We assessed the relationship between 4 PPARG SNPs (C-681G, C-689T, Pro12Ala, and C1431T) and coronary heart disease (CHD) in the PRIME (249 cases/494 controls, only men) and ADVANCE (1,076 cases/805 ...
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Type 2 diabetes is a well recognised cause of chronic renal failure (CRF). Only few oral antidiabetic drugs can be used for treating type 2 diabetes in patients with CRF. Among them are repaglinide, a rapid-acting prandial insulin releaser, and peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, such as rosiglitazone and pioglitazone. These compounds are metabolised in the li...
متن کاملPPARG ( peroxisome proliferator - activated receptor gamma )
Note: The PPAR gamma gene, a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear hormone receptors, is implicated in adipocyte differentiation and function. In order to regulate the transcription of target genes, the PPAR protein needs to form heterodimers with retinoid X receptors (RXRs). Three splice variants of PPAR gamma are known: PPAR gamma1, PPAR gamma2, ...
متن کاملPeroxisome proliferator-activated receptor gamma in osteoarthritis.
Osteoarthritis (OA) is among the most prevalent chronic human health disorders and the most common form of arthritis. It is a leading cause of disability in developed countries. This disease is characterized by cartilage deterioration, synovitis, and remodeling of the subchondral bone. There is not yet a satisfactory treatment to stop or arrest this disease process. Although several candidates ...
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ژورنال
عنوان ژورنال: Current Neuropharmacology
سال: 2007
ISSN: 1570-159X
DOI: 10.2174/157015907780077123