منابع مشابه
Baclofen overdose: defining the spectrum of toxicity.
OBJECTIVES To describe the spectrum of toxicity of baclofen in overdose, and investigate dose-related clinical effects. METHODS Consecutive baclofen overdoses were identified from a prospective database of all poisoning admissions presenting to a regional toxicology service. Ingestion was corroborated on more than one occasion and from multiple sources. Demographic, clinical and outcome varia...
متن کاملFatal toxicity of antidepressant drugs in overdose.
A fatal toxicity index (deaths per million National Health Service prescriptions) was calculated for antidepressant drugs on sale during the years 1975-84 in England, Wales, and Scotland. The tricyclic drugs introduced before 1970 had a higher index than the mean for all the drugs studied (p less than 0.001). In this group the toxicity of amitriptyline, dibenzepin, desipramine, and dothiepin wa...
متن کاملFatal serotonin toxicity caused by moclobemide and fluoxetine overdose.
Both moclobemide and fluoxetine are used in the treatment of depression, and have been shown to produce fewer side effects than conventional tricyclic antidepressants. A combination of moclobemide and fluoxetine has been used in refractory depression, however there is potential for severe serotonin toxicity. We describe a lethal case of serotonin toxicity in a 36 year-old woman after she ingest...
متن کاملA review of olanzapine-associated toxicity and fatality in overdose.
OBJECTIVE Given the increasing use of atypical antipsychotics in psychiatric populations and the very limited data concerning the safety of such drugs, we examined the available data on olanzapine in untreated overdose situations. METHODS Available toxicity data concerning olanzapine were obtained from the Offices of the Medical Examiners of Canada, the Canadian Adverse Drug Reaction Monitori...
متن کاملMetabolic Acidosis in Acetaminophen Overdose without Concurrent Liver Toxicity
Introduction Metabolic acidosis and coma are common complications of acetaminophen overdose. These affects are usually attributed to massive hepatic necrosis caused by Nacetyl-p-benzoquinoneimine (NAPQI), a toxic metabolite of acetaminophen. We describe an unusual case of lactic acidosis and coma in a patient with acetaminophen toxicity without associated hepatocellular damage as the identifiab...
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ژورنال
عنوان ژورنال: Toxicology Communications
سال: 2018
ISSN: 2473-4306
DOI: 10.1080/24734306.2018.1503850